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Sexual practices that involve higher levels of trauma to the anogenital mucosa, such as anal penetrative sex, or that occur when there is a concurrent sexually transmitted infection, including HIV or genital ulceration, present greater risks.

If there is no RNA and the immunoblot is positive, it means that the person tested had a previous infection but cleared it either with treatment or spontaneously; if the immunoblot is negative, it means that the immunoassay was wrong.Higher rates have been reported for both vertical transmission (18%, 6–36% and 41%). Breastfeeding is considered safe if the nipples are not damaged.Infection around the time of birth in one child does not increase the risk in a subsequent pregnancy.The genotypes are divided into several subtypes with the number of subtypes depending on the genotype.In the United States, about 70% of cases are caused by genotype 1, 20% by genotype 2 and about 1% by each of the other genotypes.

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